SGA placentas had significantly lower levels of NPY (p<0.05) and Ang II (p<0.05) compared to AGA placentas, with Ang II levels positively correlating with birth weight.
Observational (n=75)
Are placental levels of neuropeptide Y (NPY), angiotensin II (Ang II), and their receptors altered in Small for Gestational Age (SGA) pregnancies compared to Appropriate for Gestational Age (AGA) pregnancies?
Lower placental levels of NPY and Ang II in SGA pregnancies suggest that impaired placental neuropeptide signaling may contribute to restricted fetal growth.
p-value: p=<0.05
ABSTRACT Background Small for gestational age (SGA) births are associated with adverse health outcomes. Emerging evidence suggests that placental neuropeptides may play a role in foetal growth. However, their involvement in SGA remains underexplored. Objective This study aimed to investigate placental levels of neuropeptide Y (NPY), angiotensin II (Ang II) and their respective receptors (NPY R2, Ang II R1) in SGA pregnancies. Methods This study analysed 75 placental tissue samples (SGA = 39 and AGA = 36), collected immediately after birth. Protein levels of neuropeptides (NPY and Ang II) and their receptors (NPY R2 and Ang II R1) were measured using ELISA. Group differences between AGA and SGA were assessed using independent samples t ‐tests. Associations between placental neuropeptides and neonatal anthropometric measures were examined using linear regression analyses, with adjustments for maternal age, BMI, parity, education and baby gender. Results SGA placentas had significantly lower levels of NPY ( p < 0.05) and Ang II ( p < 0.05), while receptor levels (NPY R2, Ang II R1) did not differ significantly. Ang II and Ang II R1 levels were positively correlated with birth weight ( p < 0.05), head circumference ( p < 0.01) and chest circumference ( p < 0.01). Conclusion This study reports lower placental NPY and Ang II levels in SGA pregnancies and positive associations of Ang II and Ang II R1 with birth size. These findings suggest that impaired placental neuropeptide signalling may contribute to SGA birth.
Dangat et al. (Wed,) conducted a observational in Small for gestational age (SGA) pregnancies (n=75). SGA pregnancy vs. AGA pregnancy was evaluated on Placental levels of neuropeptide Y (NPY), angiotensin II (Ang II) and their respective receptors (NPY R2, Ang II R1) (p=<0.05). SGA placentas had significantly lower levels of NPY (p<0.05) and Ang II (p<0.05) compared to AGA placentas, with Ang II levels positively correlating with birth weight.