What question did this study set out to answer?

This case highlights metoclopramide-induced akathisia as a potential complication during pregnancy.

April 16, 2026Open Access

Akathisia Induced by Metoclopramide in a Pregnant Woman With Nausea and Vomiting: A Case Report

Key Points

This case highlights metoclopramide-induced akathisia as a potential complication during pregnancy.
Case report detailing the patient's symptoms and treatment history.
Assessment of potential drug interactions and pharmacological effects.
Consideration of administration methods impacting drug effects.
Patient experienced akathisia likely due to metoclopramide administration.
Rapid intravenous bolus increased risk of adverse effects.
Pharmacological interactions with dextromethorphan were suggested as contributing factors.

Abstract

This case suggests that metoclopramide-induced akathisia can occur during pregnancy and may be misdiagnosed as a perinatal anxiety disorder. Rapid intravenous bolus administration is a known risk factor for metoclopramide-induced akathisia and may have increased the risk in this patient. In addition, a possible pharmacological interaction between metoclopramide and dextromethorphan, including a potential CYP2D6-related pharmacokinetic effect and central dopaminergic pharmacodynamic effect, may have contributed to akathisia. Greater awareness of this adverse effect may facilitate early recognition and appropriate management.

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