What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Pregnancy (n=384). Intervention: Maternal personality traits. Primary outcome: Fetal atherogenic indices in cord blood (p=>0.05).

What question did this study set out to answer?

The study aims to explore the relationship between maternal personality traits and fetal atherogenic indices in cord blood.

April 16, 2026BMC Pregnancy and Childbirth0 citationsOpen Access

Association between maternal personality traits and fetal atherogenic indices: a cross-sectional study

LKLeyla Haghighi Kaffash MMMohammad Miri HHHafez Heydari‐Zarnagh

Key Result

Maternal personality traits were not significantly associated with fetal cord blood lipid profiles or atherogenic indices.

Key Points

The study aims to explore the relationship between maternal personality traits and fetal atherogenic indices in cord blood.
Enrolled 384 mother-newborn pairs in a cross-sectional design
Measured triglyceride, total cholesterol, and high-density lipoprotein cholesterol levels in cord plasma
Calculated low-density lipoprotein cholesterol and non-HDL cholesterol
Computed fetal atherogenic indices using various lipid ratios
Assessed maternal personality traits through the NEO Five-Factor Inventory and analyzed associations using linear regression models.
No statistically significant associations between maternal personality traits and fetal triglyceride, total cholesterol, LDL-C, HDL-C, or non-HDL-C levels
No significant associations found with fetal atherogenic indices (all p > 0.05)

Study Design

Type

Cross-Sectional (n=384)

Multicenter

Structured PICO

Are maternal personality traits associated with fetal atherogenic indices in cord blood?

Population

384 mother-newborn pairs

Intervention

Maternal personality traits assessed using the NEO Five-Factor Inventory (NEO-FFI) questionnaire

Outcome

Fetal atherogenic indices in cord blood (TG/HDL-C, TG/LDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratios, and levels of TG, TC, LDL-C, HDL-C and non-HDL-C)surrogate

Maternal personality traits do not appear to influence fetal atherogenic lipid profiles in cord blood.

Main Result

p-value: p=>0.05

Limitations

Lack of measurement of maternal blood lipid levels and atherogenic indices
Cross-sectional design cannot establish a cause-and-effect relationship
Maternal diet during pregnancy was not investigated
Lack of information about the mother's physical activity

Abstract

Personality traits have been linked to an increased risk of cardiovascular diseases in adults through the development of atherogenic dyslipidemia. However, the potential influence of maternal personality traits on fetal atherogenic indices remains unexplored. This study aimed to determine the association between maternal personality traits and atherogenic indices in cord blood. In this cross-sectional study, 384 mother-newborn pairs were enrolled. Triglyceride (TG), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) levels were measured in cord plasma. Low-density lipoprotein cholesterol (LDL-C) and non-HDL-C were calculated using TG, TC and HDL-C levels. Fetal atherogenic indices including TG/HDL-C, TG/LDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratios, were computed. Maternal personality traits were assessed using the NEO Five-Factor Inventory (NEO-FFI) questionnaire. The association between maternal personality traits and fetal atherogenic indices was examined using linear regression models. Nostatistically significant associations were observed between maternal personality traits and fetal levels of TG, TC, LDL-C, HDL-C and non-HDL-C. Additionally, no significant associations were found between maternal personality traits and any of the fetal atherogenic indices (all p > 0.05). Theresults indicate that maternal personality traits are not associated with atherogenic indices in fetal cord blood.

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