CD14+CD16- monocytes exhibit NF-κB hyperactivation in biliary atresia: Clinical association and murine therapeutic validation.

Key Points

• The research aims to investigate the role of CD14+CD16- monocytes and their NF-κB activation in biliary atresia.
• Assessment of CD14+CD16- monocytes in patients with biliary atresia
• Evaluation of NF-κB activation levels
• Therapeutic validation in a murine model
• CD14+CD16- monocytes are found in increased numbers in biliary atresia patients
• These monocytes show significant NF-κB hyperactivation
• Targeting the NF-κB pathway may reduce disease progression