What question did this study set out to answer?

The study aims to explore the role of the SSR2 gene in the development of hepatocellular carcinoma by analyzing its expression in immune cells.

April 16, 2026Open Access

Exploration of the roles of SSR2 in hepatocellular carcinogenesis based on single-cell transcriptomics and spatial transcriptomics

SLSiyuan LiuChangzhou No.2 People's Hospital XWXuyang WangAnhui Medical University DCDonghao ChengAnhui Medical University

Key Points

The study aims to explore the role of the SSR2 gene in the development of hepatocellular carcinoma by analyzing its expression in immune cells.
Utilized single-cell transcriptomics and spatial transcriptomics to analyze gene expression.
Focused on SSR2 expression levels in NK (natural killer) cells.
Assessed the impact of SSR2 on the tumor immune microenvironment.
High expression of SSR2 was found in NK cells within hepatocellular carcinoma tissue.
Increased SSR2 expression was linked to higher levels of MIF secretion.
SSR2 activation correlated with disrupted immune signaling pathways, promoting tumor progression.

Abstract

In hepatocellular carcinoma (HCC), the high expression of the SSR2 gene in NK cells is accompanied by enhanced cytoplasmic translation pathway, which promotes MIF secretion and activates its downstream signaling pathways, thereby driving the disruption of the tumor immune microenvironment and the progression of the disease.

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