Sleep deprivation accelerates Parkinson’s disease pathology by upregulating LAG3 in astrocytes and disrupting glymphatic system function

Key Points

• This research aims to explore the link between sleep deprivation, astrocytic LAG3, and Parkinson’s disease progression.
• Identified the role of LAG3 in astrocytes in relation to sleep deprivation.
• Assessed its impact on glymphatic system function and Parkinson’s disease pathology.
• Astrocytic LAG3 levels increase with sleep deprivation.
• Glymphatic dysfunction correlates with accelerated Parkinson’s disease symptoms.
• Targeting LAG3 may reduce α-synuclein pathology in affected individuals.