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Plasma membrane transporters Alp1 and Nrt1 mediate benzamidine conjugates uptake in fungi | Synapse

April 17, 2026The Cell Surface0 citationsOpen Access

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Plasma membrane transporters Alp1 and Nrt1 mediate benzamidine conjugates uptake in fungi

XJXueyang Jin YYYunfan Yang XWXue Wang

Key Points

The research aims to identify how benzamidine conjugates are taken up by fungi and the role of specific transporters in this process.
Screening of membrane transport protein mutants
Analysis of benzamidine conjugate uptake
Evaluation of antifungal activity in the presence of transporters
Alp1 and Nrt1 were identified as key transporters for benzamidine uptake
Mutants lacking these transporters showed reduced intracellular accumulation of benzamidine
Enhanced antifungal activity was observed when transporters were active

Abstract

Efflux pumps confer antifungal resistance. Benzamidine (BM) conjugates overcome resistance by enhancing intracellular accumulation, but their cellular uptake mechanism remains unclear. A screen of membrane transport protein mutants revealed that plasma membrane transporters Alp1 and Nrt1 are importers of BM conjugates and are essential for their antifungal activity.

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Cite This Study

Jin et al. (Wed,) studied this question.

synapsesocial.com/papers/69e1cdc45cdc762e9d857139 https://doi.org/https://doi.org/10.1016/j.tcsw.2026.100174

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