Laser Interstitial Thermal Therapy Enhances Bidirectional Blood-Brain Barrier Permeability in Glioblastoma

Key Points

• The central aim is to explore how laser interstitial thermal therapy (LITT) affects blood-brain barrier permeability in glioblastoma.
• Utilized laser interstitial thermal therapy (LITT) on glioblastoma models.
• Assessed changes in blood-brain barrier (BBB) integrity after treatment.
• Measured levels of circulating tumor DNA (ctDNA) post-LITT.
• LITT transiently disrupts the BBB in surrounding areas.
• Endothelial junctions show disruption and increased transcytosis following LITT.
• Enhanced ctDNA release is observed in conjunction with BBB changes.