What question did this study set out to answer?

The aim is to assess the effectiveness of platelet-rich fibrin (PRF) in reducing postoperative palatal fistula in cleft palate repair.

April 17, 2026

An RCT Evaluating the Efficacy of Using Platelet-Rich Fibrin (PRF) with Conventional Technique of Cleft Palate Repair

Key Points

The aim is to assess the effectiveness of platelet-rich fibrin (PRF) in reducing postoperative palatal fistula in cleft palate repair.
Conducted as a randomized controlled trial (RCT) with 1:1 allocation.
100 non-syndromic cleft palate patients aged 1 to 3 participated.
Patients were divided into two groups: one receiving PRF during surgery and the other undergoing standard repair without PRF.
Both groups received similar pre- and postoperative care.
Palatal fistula occurred in 6% (3 patients) of the control group without PRF.
No cases of palatal fistula were observed in the PRF group.
No wound dehiscence or postoperative bleeding was reported in either group.

Abstract

ObjectiveTo evaluate the effectiveness of platelet-rich fibrin (PRF) in the repair of cleft palate (CP), with a primary goal of reducing the occurrence of postoperative palatal fistula formation.DesignAn RCT was conducted with a 1:1 allocation ratio.SettingSingle-center study conducted in the Department of Plastic n = 100), 0% in the PRF group (n = 50), and 6% in the non-PRF group (n = 50).ConclusionsWhile PRF appears to be safe, biologically promising, and cost-effective adjunct in CP repair; the study was inconclusive as the small number of fistula occurrence limited ability to statistically substantiate its efficacy in reducing palatal fistula.

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Cite This Study

M. et al. (Wed,) studied this question.

synapsesocial.com/papers/69e1ceaa5cdc762e9d857b2d https://doi.org/https://doi.org/10.1177/10556656261422847

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