What question did this study set out to answer?

This research aims to explore the relationship between hemodynamic responses in the prefrontal cortex and depression severity as well as episode recurrence.

April 17, 2026Open Access

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Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study

Key Points

This research aims to explore the relationship between hemodynamic responses in the prefrontal cortex and depression severity as well as episode recurrence.
Cross-sectional study design
Intermittent theta burst stimulation applied to the dlPFC
Measurement of hemodynamic responses post-stimulation
Assessment of current depression state and history of episodes
Post-stimulation responses in the dlPFC correlate with current depression levels
Responses reflect a history of multiple depression episodes
Indicates the potential for using hemodynamic responses as depression vulnerability biomarkers

Abstract

Our findings align with clinical and preclinical evidence linking disrupted neurovascular function in the prefrontal cortex to depression pathophysiology. Poststimulation responses in the stimulated dlPFC, reflecting the current state and multiple prior episodes, show potential for aiding in differential diagnosis and indicating depression vulnerability. Longitudinal studies are needed to determine whether such neurological dysfunctions represent disease progression or a vulnerability biomarker.

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Cite This Study

Jin et al. (Tue,) studied this question.

synapsesocial.com/papers/69e1cf1b5cdc762e9d858032 https://doi.org/https://doi.org/10.1111/pcn.70066

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