Toxic lipid-induced epigenetic activation of ICAM1 in liver sinusoidal endothelium regulates myeloid-driven fibro-inflammatory response in MASH

Key Points

• The research aims to investigate the role of epigenetic changes in ICAM1 expression during lipotoxic stress in liver sinusoidal endothelial cells.
• Analyzed ICAM1 expression in liver sinusoidal endothelial cells under lipotoxic conditions.
• Assessed myeloid cell recruitment in a MASH model.
• Evaluated potential epigenetic modifications affecting ICAM1.
• ICAM1 expression was significantly increased in liver sinusoidal endothelial cells during lipotoxic stress.
• Enhanced recruitment of myeloid cells was observed in MASH models.
• Targeting ICAM1's epigenetic regulation might serve as a therapeutic approach for MASH.