Molecular Patterning In the Research Article (e11065), Wesley P. Wong and co-workers illustrate spatially organized, light-responsive oligonucleotides assembled on a solid substrate with high programmability. UV illumination patterns are projected by a digital micromirror device, enabling precise and flexible spatial control without the need for photomasks. This light-guided molecular patterning strategy provides a versatile and accessible approach to increase throughput in single-molecule force spectroscopy experiments.
Choi et al. (Wed,) studied this question.