The fitness and virulence of Pseudomonas aeruginosa rely on its ability to maintain a functional pool of ribosomes, which are essential for protein synthesis. This review explores the intricate ways of ribosome protection, rescue and hibernation, by which P. aeruginosa preserves ribosome functionality under stress. These processes enhance the adaptability and resistance of this pathogen to ribosome-targeting antibiotics and present significant challenges to current therapeutic strategies. By highlighting recent discoveries and identifying promising directions for future research, this review aims to explore potential targets for innovative drug discovery.
L’Hermitte et al. (Tue,) studied this question.