Adjunctive mepolizumab therapy normalized troponin and restored cardiac function after seven cycles in a patient with fulminant eosinophilic myocarditis initially managed with VA-ECMO.
VA-ECMO combined with high-dose steroids and adjunctive mepolizumab successfully managed a case of fulminant eosinophilic myocarditis, with FDG-PET proving useful for monitoring residual inflammation.
Absolute Event Rate: 0% vs 0%
Abstract Background Eosinophilic myocarditis can result from drug hypersensitivity or various systemic disorders. Although corticosteroids are effective, treatment strategies are not standardized. Case summary A 78-year-old male presented with dyspnea. On admission, he was febrile, hypotensive, and had sinus tachycardia with a newly developed right bundle branch block. Laboratory findings showed marked eosinophilia with elevated troponin. The patient rapidly progressed to cardiogenic shock, and venoarterial extracorporeal membrane oxygenation (VA-ECMO) was applied. Eosinophilic myocarditis was suspected, and endomyocardial biopsy confirmed dense myocardial eosinophil infiltration consistent with the diagnosis. Review of history revealed recent cefaclor use for a hand injury as the probable cause. The patient's condition quickly improved after initiation of high-dose intravenous methylprednisolone, allowing weaning from VA-ECMO. However, persistent troponin elevation and myocardial inflammation on fluorodeoxyglucose positron emission tomography (FDG-PET) were observed despite five weeks of steroid therapy. Subcutaneous mepolizumab, an anti–interleukin-5 monoclonal antibody, was initiated as an adjunctive immunosuppressive therapy. After seven cycles, troponin levels normalized, cardiac function fully recovered, and follow-up FDG-PET demonstrated a marked reduction in myocardial inflammation. Discussion We describe a case of fulminant eosinophilic myocarditis that was possibly associated with cefaclor use and successfully managed with VA-ECMO and adjunctive immunosuppressive therapy. FDG-PET imaging helped detect residual inflammation and assess treatment response. Immunosuppressive therapy allowed a reduction of steroid dose, mitigating the risk of steroid-related side effects.
Suh et al. (Mon,) reported a other. Adjunctive mepolizumab therapy normalized troponin and restored cardiac function after seven cycles in a patient with fulminant eosinophilic myocarditis initially managed with VA-ECMO.