Methyl maleopimarate N -Hydroxy-imide as an acid isostere in the Ugi reaction for one-pot synthesis of α-hydrazino-amides

Key Points

• The aim is to develop a one-pot method for synthesizing α-hydrazino-amides using a novel carboxylic acid isostere.
• Utilized methyl maleopimarate as a carboxylic acid isostere.
• Employed the four-component Ugi reaction in a one-pot approach.
• Focused on optimizing synthesis conditions for high yield.
• Achieved high yields of diterpene α-hydrazino-amides.
• Demonstrated the effectiveness of methyl maleopimarate as an acid isostere in the reaction.