What question did this study set out to answer?

This case report aims to emphasize the necessity of continued vigilance post-risk-reducing mastectomy in BRCA carriers.

April 17, 2026

The importance of continued vigilance after Risk Reducing Mastectomy (RRM) in BRCA carriers: a case report

CPChiara Della PepaRoyal Marsden NHS Foundation Trust GCGemma CaliendoUniversity of Campania "Luigi Vanvitelli"AMAlessia MignanoUniversity of Campania "Luigi Vanvitelli"

Key Points

This case report aims to emphasize the necessity of continued vigilance post-risk-reducing mastectomy in BRCA carriers.
Describes a case of a 70-year-old woman with a BRCA2 mutation.
Details her prophylactic surgeries for breast cancer and ovarian cancer.
Highlights findings from a follow-up period of four years.
The patient was later diagnosed with breast cancer metastasizing to the axillary lymph nodes.
Findings indicate the importance of developing dedicated follow-up protocols.
Active surveillance is critical even after risk-reducing surgery.

Abstract

Risk-Reducing Mastectomy (RRM) is safe and effective in preventing Breast Cancer (BC) in BRCA mutation carriers. Nipple Sparing Mastectomy (NSM) has become the new standard due to better esthetic result and comparable efficacy profile. After RRM the risk of developing BC still exists though hardly quantifiable due to few data in literature; here we describe the case of a 70 years old woman who was found to harbor a BRCA2 mutation after diagnosis of Ovarian Cancer (OC) in her sister, underwent prophylactic surgery for BC and OC, as per international guidelines, and four years after was diagnosed with BC, metastatic to the ipsilateral axillary lymph nodes. This case highlights the importance of going on with active surveillance after RRM and the need of developing dedicated protocols about follow up and breast imaging for these patients

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