Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy

Key Points

• This research aims to explore how base editing the TIGIT gene affects NK cell signaling and antitumor responses.
• Applied base editing technique to modify the TIGIT gene in NK cells.
• Assessed changes in inhibitory and activating signaling pathways after modification.
• Evaluated the antitumor immune response in treated NK cells.
• Modified NK cells demonstrated enhanced antitumor immunity.
• Signaling shifted from inhibitory to activating following TIGIT modification.
• Base editing shows potential as a novel strategy for improving cancer immunotherapy.