Rhodium-Catalyzed Atroposelective C-H Fluoroallylation of Heteroarenes with gem -Difluocyclopropanes

Key Points

• This research aims to develop an efficient method for atroposelective C-H allylation to create axially chiral biaryls.
• Utilized rhodium-catalyzed reactions with gem-difluocyclopropanes.
• Explored various heteroarenes as substrates.
• Analyzed reaction patterns for olefins and allyl derivatives.
• Successfully developed a new method for atroposelective C-H allylation.
• Achieved high selectivity for the desired biaryls.
• Proved the sustainability of the reaction process compared to existing methods.