Fixed drug eruption (FDE) is a form of cutaneous adverse drug reaction that reoccurs at the same location after re-exposure to the causative drug. Even though paracetamol is generally thought to be safe, three patients in this case series experienced FDE after using it. The erythematous to violaceous lesions were clearly defined and subsided when the drug was stopped. A positive rechallenge was demonstrated in one instance. Clinicians should inform patients about avoidance and alternative therapies and consider paracetamol as a possible FDE trigger.
Mishra et al. (Wed,) studied this question.
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