What question did this study set out to answer?

To develop a platinum-based drug delivery system using quercetin to treat Alzheimer's disease through targeting microglia.

April 17, 2026Journal of Materials Chemistry B0 citations

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Microglia membrane biomimetic platinum-based MOF-loaded quercetin nanodrug delivery system for the treatment of Alzheimer's disease

RZRuixin ZhaoJiangsu University MGMengrong GuoJiangsu University FYFengmei YangJiangsu University

Key Points

To develop a platinum-based drug delivery system using quercetin to treat Alzheimer's disease through targeting microglia.
Designed a membrane biomimetic system using microglia to enhance delivery.
Loaded platinum-based metal-organic frameworks (MOFs) with quercetin.
Evaluated the effectiveness in reducing β-amyloid accumulation and microglial activation.
Demonstrated decreased β-amyloid deposition in treatment groups.
Observed a reduction in oxidative stress markers.
Confirmed enhanced drug delivery efficiency to microglial cells.

Abstract

The aberrant deposition of β-amyloid (Aβ) is a central pathological hallmark of Alzheimer’s disease (AD), triggering oxidative stress, metal ion dyshomeostasis, and excessive microglial activation in a self-perpetuating pathological cascade....

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Microglia membrane biomimetic platinum-based MOF-loaded quercetin nanodrug delivery system for the treatment of Alzheimer's disease

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