Gene expression profile of adult T-cell leukemia/lymphoma with human T-cell lymphotropic virus type 1-infected Hodgkin and Reed-Sternberg-like cells is more similar to classic Hodgkin lymphoma than typical adult T-cell leukemia/lymphoma

Key Points

• The aim is to compare the gene expression profiles of adult T-cell leukemia/lymphoma and Hodgkin lymphoma.
• Examined gene expression profiles of adult T-cell leukemia/lymphoma cells
• Compared profiles with Hodgkin and Reed-Sternberg-like cells
• Utilized statistical analyses for profile similarities
• Gene expression profiles of HTLV-1-infected cells showed closer resemblance to classic Hodgkin lymphoma
• Identified key molecular markers common to both leukemias
• Suggested potential therapeutic targets based on gene expression similarities