Enhanced nanoencapsulation of gentamicin, ciprofloxacin, and lysozyme in chitosan-MIL-53 metal–organic frameworks for a synergistic activity against drug-resistant Salmonella from poultry and human origins

Key Points

• The aim is to develop a multi-agent nano-delivery system to combat drug-resistant Salmonella strains from poultry and humans.
• Development of a nano-delivery system using chitosan-MIL-53 frameworks
• Incorporation of gentamicin, ciprofloxacin, and lysozyme
• Assessment of synergistic effects against Salmonella strains
• Demonstrated controlled release of combined agents
• Significantly enhanced antibacterial activity against drug-resistant Salmonella
• Potential for improved treatment options in poultry and human infections