What question did this study set out to answer?

This research aims to determine how inhibiting endothelial SMS2 affects atherosclerosis through fatty acid oxidation.

April 18, 2026Arteriosclerosis Thrombosis and Vascular Biology0 citations

Inhibiting Endothelial SMS2 Alleviates Atherosclerosis by Blocking Endothelial‑Mesenchymal Transition Through Boosted Fatty Acid Oxidation

Key Points

This research aims to determine how inhibiting endothelial SMS2 affects atherosclerosis through fatty acid oxidation.
Examined the role of SMS2 in endothelial cells
Analyzed the impact of SMS2 inhibition using Ly93
Studied the relationship between SMS2, Wnt/β-catenin, and PPARγ
Inhibiting SMS2 reduced endothelial-mesenchymal transition (EndMT)
Increased fatty acid oxidation was observed
SMS2 activity was found to inversely affect the Wnt/β-catenin and PPARγ pathways

Abstract

SMS2 can activate the Wnt/β-catenin pathway, which is inversely correlated with the activity of PPARγ and fatty acid oxidation. This process facilitates EndMT and ED, ultimately contributing to the initiation and development of atherosclerosis. These findings suggest that inhibition of endothelial SMS2 activity with Ly93 could be beneficial for the treatment of atherosclerosis.

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Cite This Study

Zheng et al. (Thu,) studied this question.

synapsesocial.com/papers/69e3207940886becb653f7f4 https://doi.org/https://doi.org/10.1161/atvbaha.126.324346

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