Polyethyleneimine-functionalized MXene as stable two-dimensional platforms for gene delivery systems

Key Points

• The research aims to evaluate how polyethyleneimine molecular weight affects PEI-MXene hybrids for gene delivery.
• Examined chemical bonding of PEI-MXene hybrids
• Analyzed colloidal behavior and pDNA loading
• Assessed cytotoxicity and cellular uptake of the hybrids
• Hybrids exhibited reduced cytotoxicity compared to polyethyleneimine alone
• Improved cellular uptake was observed for the PEI-MXene hybrids