This study aims to investigate the clinical characteristics and long-term outcomes of patients with TH gene-related dopa-responsive dystonia (DRD), which providing further insights into this disorder. In this study, we analysed the clinical data, genetic test results and 3-year follow-up information of four patients treated with levodopa. Detailed clinical information was collected on these patients, and the results of genetic testing were analysed. Among the four patients, there were two males and two females with the age of onset ranging from 5 months to 2 years. At the same time, we review relevant literature about the clinical spectrum, treatment and prognosis.
Ren et al. (Wed,) studied this question.