Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic

Using an operationalization of clinical criteria for LATE, 8.2% of participants with MCI or dementia from our tertiary memory clinic were classified as Possible-LATE, Probable-LATE, or LATE-AD. Probable-LATE was characterized by a milder disease course than AD, whereas LATE-AD was characterized by a more aggressive disease course. This underscores the value of the proposed clinical criteria in identifying individuals with suspected LATE, who have distinct clinical trajectories from AD. Our findings, therefore, support the use of these criteria to improve diagnostic and prognostic accuracy in the memory clinic.