What question did this study set out to answer?

To explore how serum bicarbonate levels and fluid balance mediate mortality risk in critically ill patients with acute kidney injury (AKI).

April 19, 2026Open Access

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Acute Kidney Injury Complications and Kidney Replacement Therapy as Mediators of Mortality in Critically Ill Patients

VMVitor Dantas MacedoUniversidade de Fortaleza ASAndré Libório SantosUniversidade de Fortaleza ALAlexandre Braga Libório

Key Points

To explore how serum bicarbonate levels and fluid balance mediate mortality risk in critically ill patients with acute kidney injury (AKI).
Analyzed the relationship between serum bicarbonate levels and mortality risk in AKI.
Evaluated the role of kidney replacement therapy in managing AKI-associated mortality.
Examined the impact of fluid balance management on patient outcomes.
Serum bicarbonate levels and fluid balance account for about 40% of AKI-related mortality risk.
Kidney replacement therapy shows benefits for reducing mortality in patients with AKI.
Effective management of metabolic acidosis may improve outcomes beyond bicarbonate administration.

Abstract

Serum bicarbonate levels and fluid balance mediate approximately 40% of the mortality risk attributable to AKI. KRT is beneficial for AKI-associated mortality. Despite controversial results regarding the benefit of bicarbonate administration in AKI, the focus should remain on how managing metabolic acidosis-possibly beyond simple bicarbonate replacement-in combination with improved fluid balance management can enhance outcomes in critically ill patients with AKI.

AI से पूछें

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AI से पूछें

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View Full Paper

Acute Kidney Injury Complications and Kidney Replacement Therapy as Mediators of Mortality in Critically Ill Patients

Key Points

Abstract

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