Platelet factors 4 produces an antidepressant effect in mice via inhibition of neuroinflammation

Key Points

• To investigate the antidepressant effects of platelet factors 4 (PF4) and its mechanism related to neuroinflammation.
• Utilized mouse models to assess behavioral changes after PF4 administration.
• Monitored neuroinflammatory responses in the nucleus accumbens (NAc).
• Conducted assessments to evaluate the potential antidepressant effects of PF4.
• PF4 treatment led to significant reductions in neuroinflammatory markers in the NAc.
• Mice exhibited behavioral improvements associated with reduced depressive-like symptoms.
• PF4 shows potential as a therapeutic target for major depression.