Abstract：Objective：The bidirectional Mendel randomization（MR）analysis method was adopted. To explore the causal association between Diabetic retinopathy（DR）and Neovascular glaucoma（NVG）. Methods：In the genome-wide association study（GWAS）of the European population，19 single nucleotide polymorphisms（SNPs）related to DR And 13 SNPs related to NVG were used as instrumental variables. The inverse variance weighting（IVW）method，weighted median method（WME），simple model（SM），weighted model（WM），and MR Egger method were used to explore the causal association between DR And NVG diseases. Results：（1）Bidirectional MR Analysis results：DR Is not a risk factor for the occurrence of NVG（IVW analysis results：β = 0.024，SE = 0.055，P > 0.05）. NVG may be a risk factor for the occurrence of DR（IVW analysis result：β= 0.141，OR=1.151，95% CI：1.017-1.304，P<0.05）.（2）Sensitivity analysis：DR Was the exposure and NVG was the outcome，NVG was the exposure and DR Was the outcome. There was no evidence of horizontal pleiotropy among the selected NSNPS，and theselected instrumental variables were reliable. The results of the retention method sensitivity analysis showed that regardless of whether DR Was the exposure and NVG was the outcome，or NVG was the exposure and DR Was the outcome，no specific SNPs had a significant change in the MR Results.（3）Heterogeneity test：DR Was the exposure and NVG was the outcome，and there was significant heterogeneity among different methods；NVG was the exposure and DR Was the outcome，and there was no significant heterogeneity among different methods. Conclusion：NVG may be a risk factor for DR Occurrence，while DR Is not a risk factor for NVG occurrence.
Ye et al. (Thu,) studied this question.