What question did this study set out to answer?

This research aims to identify risk factors associated with distant recurrence in rectal cancer patients.

April 19, 2026Open Access

Risk factors for distant recurrence in patients with rectal cancer supporting selection for total neoadjuvant therapy

ASAnna Baech SlipsagerAalborg University Hospital RBR BahijOdense University Hospital HCHeidi Søgaard ChristensenAalborg University

Key Points

This research aims to identify risk factors associated with distant recurrence in rectal cancer patients.
Analyzed cT-stage and cEMVI status in rectal cancer patients.
Assessed distance to the mesorectal fascia (MRF) in the evaluation process.
Utilized prognostic features to stratify risk for neoadjuvant treatment.
cT-stage is a significant predictor of distant recurrence.
cEMVI status strongly correlates with prognosis in these patients.
Distance to MRF influences treatment strategy decisions significantly.

Abstract

In this study, cT-stage, cEMVI status, and distance to MRF are prognostic features for risk stratification for patients receiving neoadjuvant radiotherapy. These results may be used for selecting patients for future treatment strategies such as TNT.

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