What question did this study set out to answer?

The aim is to explore a new Pd(II)-catalyzed method for regioselective modifications of indoles.

April 19, 2026Organic & Biomolecular Chemistry0 citations

2-Pyridyl Sulfoxide Directed Pd(II)-Catalyzed Regioselective C2- Arylation/Alkenylation of Indoles

KYKanchan YadavRabindranath Tagore Medical College RJRam Singh JatIndian Institute of Technology Delhi RSRitesh SinghUniversity of Delhi

Key Points

The aim is to explore a new Pd(II)-catalyzed method for regioselective modifications of indoles.
Utilized Pd(II) as a catalyst for reactions.
Employed 2-pyridyl sulfoxide as a directing group.
Conducted reactions with iodoarenes and both activated and unactivated alkenes.
Achieved regioselective C2-arylation and alkenylation of indoles.
Demonstrated effectiveness with various iodoarenes and alkenes.

Abstract

The present study reports a Pd(II)-catalysed regioselective C2-arylation and alkenylation of indoles using iodoarenes and activated/unactivated alkenes, respectively, directed by 2-pyridyl sulfoxide at the C3-position of indole for the first...

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