Levofloxacin promotes extracellular matrix remodeling and induces apoptosis of heart valve interstitial cells by modulating MMP, collagen, and elastin expression.
Does levofloxacin promote extracellular matrix remodeling and apoptosis in heart valve interstitial cells?
Levofloxacin induces extracellular matrix remodeling and apoptosis in heart valve interstitial cells, suggesting a potential mechanism for drug-induced pathological heart valve remodeling.
Absolute Event Rate: 0% vs 0%
Levofloxacin promoted extracellular matrix remodeling by modulating the expression levels of MMP, collagen and elastin, and inducing apoptosis of valve interstitial cells, which may contribute to pathological remodeling of heart valves.
Zhang et al. (Thu,) reported a other. Levofloxacin promotes extracellular matrix remodeling and induces apoptosis of heart valve interstitial cells by modulating MMP, collagen, and elastin expression.