Autoantibodies to Joint‐Related Peptides Are Associated with Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Key Points

• The aim is to identify biomarkers that predict the onset of rheumatoid arthritis in individuals who are seronegative.
• Identified novel autoantibodies to joint-related peptides.
• Evaluated their association with rheumatoid arthritis onset.
• Compared the specificity of these biomarkers in differentiating between rheumatoid arthritis and osteoarthritis.
• The biomarkers can effectively identify presymptomatic, seronegative individuals at high risk for rheumatoid arthritis.
• The biomarkers showed high specificity in distinguishing early seronegative rheumatoid arthritis from osteoarthritis.