TERT promoter–mutated thyroid carcinomas: prognostic and histologic insights according to the WHO 2022 classification

Key Points

• This research aims to explore the twofold significance of TERT promoter mutations in thyroid carcinomas, focusing on their morphological diversity and prognostic implications.
• Analyzed histologic features of TERT promoter-mutated thyroid carcinomas.
• Compared findings with the WHO 2022 classification.
• Assessed implications for risk stratification.
• Expanded recognition of morphologic characteristics associated with TERT mutations.
• Demonstrated the need for routine evaluation of these features in thyroid carcinoma assessments.
• Highlighted the potential for improved identification of aggressive tumors.