Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

Key Points

• This research aims to determine how leptin affects eosinophil behavior and angiogenesis in chronic rhinosinusitis with nasal polyps (CRSwNP) under Type 2 inflammation.
• Examined the role of leptin in eosinophil migration and angiogenesis.
• Analyzed the involvement of chemokine ligands and PAI-1.
• Investigated the effects in a Type 2 inflammatory context.
• Leptin significantly promotes eosinophil chemotaxis.
• Increased angiogenesis was noted in the presence of leptin.
• The findings suggest a potential role of leptin in worsening CRSwNP.

Abstract