Design, synthesis, and antidiabetic activity of new furan-clubbed 1,2,3-triazole derivatives as α -glucosidase inhibitors

Key Points

• The aim is to design and evaluate new triazole derivatives as α-glucosidase inhibitors for their antidiabetic effects.
• Synthesis of furan-clubbed 1,2,3-triazole derivatives
• In vitro and in vivo testing of PD-10
• Molecular docking analysis for interaction assessment
• PD-10 shows significant α-glucosidase inhibitory activity
• Strong antidiabetic effects observed in in vitro assays
• Promising results in in vivo models supporting its potential for development