What question did this study set out to answer?

This case report aims to explore the effectiveness of a specific antibiotic combination for treating severe infections by pan-drug-resistant Pseudomonas aeruginosa ST244.

April 19, 2026Open Access

Combination of Ceftazidime-Avibactam and Meropenem for the Treatment of Pneumonia and Bloodstream Infections Caused by Pan-Drug Resistant Pseudomonas aeruginosa ST244: A Case Report

YKYixin KangNankai University SKSuhai KangNanjing Medical University JCJunchang CuiNankai University

Key Points

This case report aims to explore the effectiveness of a specific antibiotic combination for treating severe infections by pan-drug-resistant Pseudomonas aeruginosa ST244.
Presented a case of a woman with pneumonia and bloodstream infections post-surgery.
Identified strain as pan-drug resistant Pseudomonas aeruginosa ST244.
Administered ceftazidime/avibactam and meropenem therapy.
Patient showed successful treatment with the antibiotic combination.
Indicates that CAZ/AVI and MEPM can be effective against severe PDR-PA infections.

Abstract

Case Presentation: We describe a challenging case of a woman with Pseudomonas aeruginosa pneumonia and bloodstream infections following cardiothoracic surgery. This strain exhibited a pan-drug resistance phenotype belonging to the high-risk clone ST244. Finally, she was successfully treated by antibiotic therapy with ceftazidime/avibactam (CAZ/AVI) and meropenem (MEPM). Conclusion: This case suggests that the combination of CAZ/AVI and MEPM may represent a potential therapeutic option for severe infections caused by pan-drug-resistant Pseudomonas aeruginosa (PDR-PA). Keywords: ceftazidime/avibactam, meropenem, pan-drug resistance, Pseudomonas aeruginosa

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