Herein, we have synthesized the commonly known protonated 5,10,15,20‐tetrakis(4‐pyridyl)porphyrin (compound 1 ) and a mixed‐linker zinc‐based metal–organic framework (compound 2 ) and evaluated their antibacterial photodynamic therapy. The crystal structure of 1 exhibits hydrogen‐bonded scaffolds and engages in π‐stacking interactions, whereas compound 2 is coordinated through zinc metal nodes to porphyrin and terephthalate ions, forming an interpenetrated 3D framework with a mog topology. In 2 , we observed a high theoretical surface area of 2915 m 2 g −1 calculated using a N 2 apparatus. Molecular orbital calculations confirm that the highest occupied and lowest unoccupied molecular orbitals are mainly localized on the porphyrin core, with the terephthalate linker acting as an electronic spacer. Finally, 2 exhibits an enhanced reactive oxygen species production and superior antibacterial activity compared to 1 under irradiation with red light. These performances clearly resulted in inhibition zones of 28±1 mm (MRSA) and 21±1 mm ( Escherichia coli ) and strong binding properties to the proteins. These findings demonstrate that 2 functions as a robust, light‐activated antibacterial platform and provide a rational route for next‐generation antibacterial agents.
Shivam et al. (Fri,) studied this question.