有机新污染物与抗生素抗性质粒相互作用及效应

Key Points

• This research aims to explore the interaction mechanisms and environmental effects between emerging organic pollutants and antibiotic resistance plasmids.
• Analysis of the interaction mechanisms in various environmental media.
• Investigation of the impact on plasmid stability, enzyme sensitivity, and environmental persistence.
• Assessment of microbial community structure changes due to these interactions.
• EOCs directly alter ARPs through binding, chemical damage, and degradation.
• Observed a dose-dependent 'low-promote high-inhibit' effect on antibiotic resistance gene migration.
• EOCs and ARPs together reshape resistance transmission patterns and enhance public health risks.