Charge-regulated hepatic γ -glutamyltranspeptidase fluorescent probe: in vivo staging Schistosoma -infection

Key Points

• The aim is to develop a sensitive and real-time diagnostic tool for monitoring Schistosoma infection in the liver.
• Development of a charge-regulated fluorescent probe
• In vivo application in a relevant animal model
• Evaluation of probe sensitivity and specificity against traditional methods
• The probe successfully detected Schistosoma infections in real-time
• Demonstrated higher sensitivity compared to microscopy
• Effectively staged the infection based on hepatic γ-glutamyltranspeptidase levels