Bioinspired antimicrobial peptide hydrogel dressing for the accelerated healing of infected wounds
Key Points
The aim is to evaluate the effectiveness of a chitosan-based hydrogel dressing for wound healing.
Developed a hydrogel dressing using chitosan enriched with gramicidin and trehalose
Tested the dressing in an infected rat wound model
Assessed antimicrobial activity and wound healing rate
The hydrogel dressing significantly enhanced antimicrobial activity
Accelerated wound healing observed compared to control treatments
Demonstrated synergy between gramicidin and trehalose in promoting healing
Abstract
A chitosan (CS)-based hydrogel dressing enriched with gramicidin (GCN) and trehalose (TH) enhances antimicrobial activity and accelerates wound healing in an infected rat wound model.