Design, synthesis, nematicidal activity, and preliminary mechanism of pyrimidine derivatives through the scaffold hopping strategy

Key Points

• The aim is to synthesize and evaluate novel pyrimidine derivatives as effective nematicides.
• Designed and synthesized pyrimidine derivatives using a scaffold hopping strategy.
• Assessed nematicidal activity against nematodes in laboratory conditions.
• Optimized scaffold structure for enhanced effectiveness.
• Identified promising pyrimidine derivatives with significant nematicidal activity.
• Demonstrated the potential of the scaffold for developing new compounds.