Synthesis, characterization, in vitro and computational assessment of new xanthene hydrazone derivatives as promising vasorelaxant agents

Key Points

• The research aims to synthesize and assess the vasorelaxant properties of xanthene hydrazone derivatives.
• Synthesis of novel xanthene-hydrazone derivatives
• Structural characterization
• In vitro evaluation of vasorelaxant properties
• Computational assessment using in silico approaches.
• The synthesized derivatives exhibited significant vasorelaxant activity
• Characterization confirmed their structural integrity
• In silico analysis provided insights into their potential mechanisms of action.