What question did this study set out to answer?

To investigate the role of miR-214-3p in regulating cisplatin resistance in oral squamous cell carcinoma (OSCC) through ferroptosis.

April 19, 2026Journal of Oral Pathology and Medicine0 citations

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Effect of miR ‐214‐3p on Cisplatin Resistance in Oral Squamous Cell Carcinoma by Regulating Ferroptosis Through Targeting GPX4

RZRongxia Zhang JZJing Zhang YQYongle Qiu

Key Points

To investigate the role of miR-214-3p in regulating cisplatin resistance in oral squamous cell carcinoma (OSCC) through ferroptosis.
Analyzed the expression levels of miR-214-3p and GPX4 in OSCC cells
Conducted experiments to assess ferroptosis induction
Investigated the relationship between miR-214-3p and cisplatin resistance
miR-214-3p was found to inhibit GPX4 expression
Inhibition of GPX4 triggered ferroptosis in OSCC cells
miR-214-3p competent cells showed reduced resistance to cisplatin

Abstract

Our findings reveal a novel miR-214-3p/GPX4/ferroptosis axis in OSCC DDP resistance. miR-214-3p suppresses GPX4 to promote ferroptosis, thereby reversing DDP resistance. This study identifies miR-214-3p as a potential therapeutic target for overcoming chemoresistance in OSCC by modulating ferroptosis.

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Cite This Study

Zhang et al. (Thu,) studied this question.

synapsesocial.com/papers/69e4741c010ef96374d8fe58 https://doi.org/https://doi.org/10.1111/jop.70138

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