Predictive Value of Baseline Thyroid Autoantibody Titers for ICI-Associated Thyroid Adverse Events in Cancer

Key Points

• This research aims to evaluate how baseline thyroid autoantibody levels can predict thyroid-related adverse events during cancer immunotherapy.
• Measured baseline levels of TPOAb and TgAb in patients undergoing cancer immunotherapy.
• Analyzed the correlation between autoantibodies and incidence of thyroid adverse events (irAEs).
• Utilized quantitative screening for risk assessment.
• Higher levels of TPOAb were associated with an increased risk of thyroid irAEs.
• Baseline screening effectively stratified patients based on their risk.