What question did this study set out to answer?

To review the synthesis and anticancer potential of pyrimidine-based heteroaryl compounds.

April 21, 2026

Design and Synthesis of Pyrimidine-Based Heteroaryl Compounds and their Applications for the Treatment of Cancer

Key Points

To review the synthesis and anticancer potential of pyrimidine-based heteroaryl compounds.
Reviewed literature on pyrimidine derivatives from 2018 to 2023
Explored in vitro studies on various malignancies
Analyzed molecular docking studies related to anticancer activity.
Identified multiple pyrimidine derivatives with promising anticancer effects
Synthesis methods for new pyrimidine analogs were discussed
Highlighted the efficacy of pyrimidines as scaffolds for drug development.

Abstract

Abstract: Pyrimidines are nitrogen-containing singular heterocycles renowned for having a broad spectrum of therapeutic applications in anticancer and antiviral drug development. Many anticancer drugs that are sold commercially contain pyrimidine moieties. Based on these findings, the synthesis of several possible pyrimidine derivatives with anticancer activity, reported between 2018 and 2023, is thoroughly explained in this review. Further, this review highlights the in vitro and molecular docking studies of several malignancies. Recent advances in the synthesis of pyrimidine analogs, along with their anticancer activity reported in this review, make this heterocyclic moiety an attractive scaffold for discovering newer anticancer drugs.

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Cite This Study

Singha et al. (Tue,) studied this question.

synapsesocial.com/papers/69e7138bcb99343efc98d164 https://doi.org/https://doi.org/10.2174/0113852728456999260406102859

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