Draft genome sequences analyses of 25 NDM-producing Escherichia coli isolates from pediatric gut samples in Shenzhen, China

Key Points

• The research aims to analyze the genome sequences of NDM-producing Escherichia coli strains to understand their resistance and virulence.
• Analyzed 25 isolates of carbapenem-resistant E. coli from pediatric gut samples.
• Identified 24 strains with NDM-5 and one with NDM-1 through genomic sequencing.
• Examined resistance mechanisms and virulence factors in the isolates.
• Identified predominant NDM-5 strain in the majority of isolates.
• Confirmed the presence of virulence factors linked to infection risk.
• Suggested important implications for infection control and treatment approaches in pediatrics.