These observations indicate that loss of nuclear compartmentalization is an early, irreversible event in heat-induced cell death. Because nuclear pore complex (NPC)-mediated selective macromolecular transport is indispensable for cell survival, irreversible NPC damage appears to severely limit cellular recovery. Irreversible impairment of NPC selectivity is therefore proposed as the most parsimonious explanation for observed heat-induced nuclear leakiness.
Samsonova et al. (Mon,) studied this question.