In recent years, deep learning has been applied more and more to medical image analysis. One such application of deep learning is the automated polyp detection in colonoscopy with the target of reducing miss rates. This study presents a comprehensive evaluation of nine state-of-the-art object detection models for colonic polyp detection: YOLOv8, YOLOv9, YOLOv10, YOLO11, YOLO12, YOLO26, RT-DETR, YOLO-World, and YOLOE. The models were evaluated on three publicly available datasets: CVC-ClinicDB, CVC-ColonDB, and ETIS-LaribPolypDB. All models were trained under standardized conditions using identical hyperparameters and data augmentation strategies to guarantee fair comparison. Performance was evaluated using multiple metrics: mAP@50, mAP@50–95, F1 score, precision, recall, inference time, and computational cost. YOLO11 demonstrated the best overall performance, achieving mAP@50 scores of 0.995, 0.944, and 0.978 on the three datasets respectively, while maintaining the fastest inference time of approximately 150 ms per image and the third-lowest computational cost at 21.3 GFLOPs. Cross-dataset generalization experiments revealed a significant loss of performance, with mAP@50 dropping by 20–40% when models were tested on an unseen dataset, highlighting the challenge of true generalization with limited datasets. Statistical analysis by polyp size showed that while all models achieved F1 scores exceeding 0.95 for large polyps, performance decreased to 0.60–0.85 for small polyps, indicating a limitation in detecting small lesions. The analysis of failure modes showed that missed detections, false positives and boundary errors constitute 60–75% of all failures, suggesting that domain adaptation of object detection models may be required.
Portase et al. (Mon,) studied this question.