Abstract Painful diabetic neuropathy (PDN) is a debilitating complication of diabetes, yet its central nervous system pathogenesis remains poorly understood. We investigated transcriptomic alterations in the central amygdala (CeA) in a diabetic rat model exhibiting neuropathic pain behavior. Male Sprague-Dawley rats were intraperitoneally injected a single dose of streptozotocin to induce diabetes. Six weeks following administration, the development of neuropathic pain was confirmed by the von Frey filament test. Subsequently, RNA sequencing of the CeA tissues was performed. This dataset provides a transcriptomic resource of the CeA in a rat model of diabetes-associated neuropathic pain, which is publicly available to facilitate research into the central mechanisms of PDN.
Nie et al. (Mon,) studied this question.